Searchable abstracts of presentations at key conferences in endocrinology

ea0056p654 | Endocrine tumours and neoplasia | ECE2018

Fibroblast-kinome silencing to identifies putative mediator of Triple-negative breast cancer (TNBC) invasion

Gagliano Teresa , Vella Viviana , Bienkowska Kamila , Ditsiou Angeliki , Giamas Georgios

Kinases represent a main therapeutic targets in cancer treatment as their impairing is related to tumor growth and progression. Despite the increasing evidence that tumor microenvironment (TME) signaling influences the behavior of surrounding cancer epithelial cells, still little is known about what changes in stromal cells influence tumor cellsÂ’ behavior. TNBC patients are still lacking an effective therapy, as not much is known about the biology of this BC tumor subtype...